High-mobility Group Box 1 Protein Initiates Postoperative Cognitive Decline by Engaging Bone Marrow–derived Macrophages
نویسندگان
چکیده
منابع مشابه
High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages.
BACKGROUND Aseptic trauma engages the innate immune response to trigger a neuroinflammatory reaction that results in postoperative cognitive decline. The authors sought to determine whether high-mobility group box 1 protein (HMGB1), an ubiquitous nucleosomal protein, initiates this process through activation and trafficking of circulating bone marrow-derived macrophages to the brain. METHODS ...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2014
ISSN: 0003-3022
DOI: 10.1097/aln.0000000000000045